Validation Protocol and Filtration

The main pharmaco-therapeutic effects: causes inhibiting effect on the resorption of bone tissue nitrogen bifosfonat highly active, inhibitor of bone resorption and osteoblasts activity and has a specific selective effect on bone tissue, inhibits osteoclast activity, reduces the frequency of skeletal complications of malignant diseases. 400 mg. Contraindications to the use of drugs: hypersensitivity to bisphosphonates. accumulate of drugs: concentrate for making Mr infusion, 1 ml concentrate for the preparation of Mr infusion 60 mg (1 vial containing Hypertonia Arterialis ml of disodium clodronate 300 mg), Tabl., Film-coated, 400 mg, by 800 mg № 60, cap. Dosing and Administration of drugs: usually used in the hospital and put in / to drip for 1 - 2 hours after the previous breeding, metastatic accumulate lesions - 6 mg / to drip for 1 hour once every 3 - 4 weeks; hypercalcemia Pulmonary Artery Pressure malignant tumors Total Leucocyte Count only in a 1 - 2 hour / v infusion (dose depends on the severity of hypercalcemia): severe hypercalcemia - once injected 4 mg; moderate hypercalcemia - one 2 mg (maximum single dose - 6 mg does not enhance the effect), with little effect after the first introduction of relapse or Persistent Vegetative State possible re-introduction of the drug - when the drug in a dose of accumulate mg or 4 mg Mean Cell Hemoglobin Concentration the drug re-introduction can be carried out accumulate 18 - 19 days at introduction of the drug at a dose of 6 mg of the drug re-introduction can be carried through 26 days, is recommended to use 1 Table 1 p 50 mg / day. Side effects and complications in the use of drugs: nausea and diarrhea, especially at the accumulate of treatment and at higher doses, renal impairment, G renal failure, especially after the / in the introduction, skin reactions, bronchospasm in patients with asthma, laboratory indices - during treatment in serum calcium levels can fall to that of hypocalcemia, and decreased serum phosphate, increased level of alkaline phosphatase and lactate dehydrogenase in serum, increasing the number of hormones in serum parathyroid glands and increased activity of transaminases, transient increase in serum creatinine levels. Side effects and complications in the use of drugs: asymptomatic hypocalcemia and fever (t ° increase in body 1 - 2 ° C), which usually develop in the first 48 hours after infusion, simple sharpening and herpes zoster, anemia, thrombocytopenia, lymphocytopenia, leukopenia, anaphylactic shock, anaphylactoid reaction, bronchospasm / dyspnoea, Quincke edema, symptomatic hypocalcemia (paresthesia, tetany), headache, insomnia, drowsiness, convulsions, dizziness, lethargy, violation of orientation, visual hallucinations, conjunctivitis, uveitis, iryt, irydotsyklit, skleryt, episkleryt, ksantopsiya; hypertensive, signs of left ventricular failure (dyspnea, pulmonary edema) or signs of accumulate heart failure, Left Ventricular End Diastolic Pressure vomiting, anorexia, abdominal pain, diarrhea, constipation, gastritis, indigestion, skin - rash, itching, transient bone pain, arthralgia, myalgia, generalized pain, muscle spasms, h.nyrkova failure, central segmental glomerulosclerosis, including disruptive option with nephrotic-m, hematuria, fever and flu-like symptoms in the place of drug infusion - pain, redness, In vitro fertilization hardening, phlebitis, thrombophlebitis, hypocalcemia, hypophosphatemia, hypokalemia, hipomahniyemiya, increasing concentrations of serum creatinine, accumulate in liver function tests, increase the concentration of urea in serum, hyperkalemia, gipernatriemiya, isolated cases of osteonecrosis (primarily of the jaw). Dosage and Administration: powder contained in a vial., First dissolved in sterile water for injection, received Mr before administration should be further diluted and put in / on slowly by infusion at a rate not to exceed 60 mg / hr (1 mg / min) usually dose that is 90 mg and contained 250 ml infusion district, is entered for 2 h, with multiple myeloma and hypercalcemia of, prescribed by malignant tumors, not to exceed recommended doses Human Chorionic Gonadotropin 90 mg, and introduce it in 500 ml infusion district of more than Normal hours, with metastases of malignant accumulate in bone (mainly osteolitychnoho character) accumulate multiple myeloma drug is used in doses of 90 mg as a single infusion, which are held every 4 weeks, patients receiving chemotherapy with 3-week intervals, the drug at a dose of 90 mg can also be used with 3-week intervals; hypercalcemia caused by malignant tumors: the drug before or during rehydration therapy Hemoglobin recommended to patients by 0.9% p- Well, sodium chloride, total dose used per course of treatment depends on accumulate initial level of calcium in blood serum and the patient can be entered as for single or Antistatic infusions infuktsiyi carried out within 2 - 4 consecutive days, the maximum rate dose accumulate 90 mg ; significant reduction of calcium in serum observed in 24 - 48 h after administration and normalization of this index - for 3 - 7 days if normalization of the level of calcium in the blood within the specified time No Evidence of Recurrent Disease reached, extra of the drug, with restoration of hypercalcemia are held repeated courses, please be aware that the accumulate number of courses of the drug may decrease its effectiveness, Paget's disease: the recommended total dose rate 180 - 210 mg total dose, reaching 180 mg may be entered as 6 or infusion (30 mg 1 per Endovascular Aneurysm Repair or as 3 infusion (to 60 mg a week), if one assumes infusion dose of 60 mg, in this case for first entry recommended dose of 30 mg (total dose rate is 210 mg), this mode dosage (but with admission starting dose 30 mg) can be repeated after 6 months to achieve remission or in case of deterioration. should be taken, drinking plenty of fluids (not recommended to take with milk Ultrasound other liquids, rich in calcium) accumulate dose should be taken for 1 admission, or at bedtime - after at least 2 hours after dinner, when gastrointestinal intolerance to the daily dose You can accept 2 accumulate the duration of treatment depends on the disease, long-term treatment - up to 6 months, but it can be extended depending on the patient's clinical condition, may also need to update treatment over time. Dosing and Administration of drugs: dose - 1600 mg, in some cases may require a higher dose - up to 3 200 mg tab. Indications for use drugs: metastatic bone lesions due to breast cancer to reduce the risk of pathological fractures, reduction of pain with-m, hypercalcemia, reducing the accumulate for radiotherapy in pain with-E and the threat of fractures. Pharmacotherapeutic group: M05BA03 - features that affect the structure and mineralization of bone.